Diffusion-weighted imaging reversal after reperfusion therapy in acute ischemic stroke: associations with white matter hyperintensities and cerebral microbleeds.
AUTHORS
Bannert, Nora; Klassen, Paula Cynthia; Krijatov, Regina; et al.
PUBLISHED IN
Neurological research and practice Vol. 8, no. 1, p. 90
ABSTRACT EXCERPT
White matter hyperintensities (WMH) and cerebral microbleeds (CMBs) are common MRI markers of chronic small-vessel brain injury and have been associated with adverse outcomes after ischemic stroke. However, whether these markers influence early ischemic tissue reversibility following reperfusion the
Efficacy and tolerability of D-β-hydroxybutyrate ester in patients with amyotrophic lateral sclerosis (KETO-ALS)–a randomised, placebo-controlled, double-blind study
AUTHORS
Herrmann, Christine; Jagodzinski, Luisa; Elmas, Zeynep; et al.
PUBLISHED IN
EClinicalMedicine Vol. 101, p. 104272 -
ABSTRACT EXCERPT
Background: Hypermetabolism and weight loss are prominent features of amyotrophic lateral sclerosis (ALS). Here, we sought to target the energy deficit in ALS by applying oral ketone bodies as high-energetic substrates. Methods: Patients with probable or definite ALS were enrolled to this randomised
SNP rs11618521 modifies transcription factor NANOG-mediated expression of KPNA3 and the age at onset of spinocerebellar ataxia type 3.
AUTHORS
Han, Hezhou; Czisch, Leah; Wanner, Manuel Pascal; et al.
PUBLISHED IN
Acta neuropathologica Vol. 152, no. 1, p. 63
ABSTRACT EXCERPT
Intranuclear localization of the affected protein ataxin-3 is critical for the pathogenesis of spinocerebellar ataxia type 3 (SCA3). The nuclear-cytoplasmic transporter karyopherin alpha 3 (KPNA3) has been demonstrated to play an essential role in the pathophysiology of this disorder. In this study,
A prospective observational study measuring the stability of plasma pTau181 using the Elecsys Phospho-Tau (181P) plasma immunoassay for early detection of Alzheimer's disease.
AUTHORS
Kurz, Carolin; Leonhardt, Sophia; Hufnagel, Anna; et al.
PUBLISHED IN
Alzheimer's research & therapy Vol. 18, no. 1, p. 240
ABSTRACT EXCERPT
Plasma tau phosphorylated at threonine 181 (pTau181) is a key blood-based biomarker that correlates with the burden of amyloid-beta (Aβ) pathology in Alzheimer's disease (AD). The Elecsys® Phospho-Tau (181P) Plasma (pT181p) immunoassay (Roche Diagnostics International Ltd, Rotkreuz, Switzerland) is
Vascular endothelial growth factor A induces proliferation of adult neural progenitor cells in non-neurogenic periventricular regions of the adult mouse hindbrain.
AUTHORS
Fauser, Mareike; Bockholt, Roy; Keiner, Silke; et al.
PUBLISHED IN
Neuroreport Vol. 37, no. 17, p. 722 - 730
ABSTRACT EXCERPT
In addition to the well-established neurogenic niche of the ventricular-subventricular zone (V-SVZ) of the lateral ventricles, neural stem/progenitor cells (NPCs) have been identified in the periventricular regions (PVRs) throughout the adult mouse ventricular system. The potential role of these NPC
Stroke-CORE: master study protocol of the national cohort of the specialty network stroke within the network university medicine in Germany.
AUTHORS
Wiegand, Flora Noelle; Alonso, Angelika; Audebert, Heinrich J; et al.
PUBLISHED IN
Neurological research and practice Vol. 8, no. 1, p. 92
ABSTRACT EXCERPT
Although Germany has a strong history of stroke research, it currently lacks a national harmonised infrastructure for clinical stroke research. To address this gap, the stroke-specific Specialty Network (SN Stroke) of the Network University Medicine (NUM) was established as a comprehensive research
Tau positron emission tomography harmonization using the CenTauR approach: General conversion equations, relevant cut-points, and external validation.
AUTHORS
Moscoso Rial, Alexis; Leuzy, Antoine; Raket, Lars Lau; et al.
PUBLISHED IN
Alzheimer's and dementia Vol. 22, no. 10, p. e71886
ABSTRACT EXCERPT
Tau positron emission tomography (PET) tracers differ in kinetics, binding properties, and quantification pipelines, complicating cross-study comparisons. The CenTauR approach provides a unified framework for harmonizing tau PET quantification across tracers.We defined a tracer-agnostic 'Standard Me
Intrinsic cellular persistent firing sustains hippocampal spatial representations during working memory.
AUTHORS
Saber Marouf, Babak; Reboreda, Antonio; Theissen, Frederik Mark; et al.
PUBLISHED IN
Science advances Vol. 12, no. 44, p. eaef9907
ABSTRACT EXCERPT
Neurons are the fundamental units of cognitive processing. The prevailing view holds that neurons are input-output units that fire action potentials only upon receiving sufficient synaptic input. Here, we demonstrate that this may not be the sole operational mode of neurons in vivo during cognitive
Visual acuity changes in idebenone treatment‑naïve patients with Leber hereditary optic neuropathy: insights from the CRS-2 study.
AUTHORS
Krawczynski, Maciej R; van Everdingen, Judith; Leroy, Bart P; et al.
PUBLISHED IN
Journal of neurology Vol. 273, no. 11, p. 690
ABSTRACT EXCERPT
Case Record Survey (CRS)-2 was an international, multicenter, retrospective study designed to characterize the natural history of vision loss and spontaneous recovery in patients with Leber hereditary optic neuropathy (LHON).Case records of idebenone treatment-naïve patients aged ≥12 years, with mit
Detection of Age-Related Cognitive Decline Over Short Time Frames Using Digital Multiday Learning Assessments: Longitudinal Study.
AUTHORS
Blotenberg, Iris; Kim, Hairin; Soberanes, Daniel; et al.
PUBLISHED IN
JMIR aging Vol. 9, p. e100917 - e100917
ABSTRACT EXCERPT
High-resolution digital cognitive tools administered at frequent intervals enable the study of age-related cognitive change at a previously unattainable level of granularity. Computational modeling further enables the simultaneous examination of multiple aspects of cognitive performance.The objectiv